Sertraline versus other antidepressive agents for depression

Antifungal agents: Polyene, azole, antimetabolite, other and future agents

Antifungals have always been considered as one of the astonishing discoveries of the 20th century. This is correct, but the real marvel is the development of antifungal resistance in hospitals, communities, and the environment concomitant with their use. Fungal infections have emerged as an important clinical threat, with significant associated morbidity and mortality.  This study is desig...

Randomized trial of sertraline versus venlafaxine XR in major depression: efficacy and discontinuation symptoms.

BACKGROUND The comparative efficacy of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) was recently debated. Meta-analyses, based mainly on fluoxetine comparator data, suggest that the SNRI venlafaxine has superior efficacy to SSRIs in treatment of major depression. OBJECTIVE To compare quality of life (QOL), efficacy, safety, and toler...

Efficacy of sertraline in prevention of depression recurrence in older versus younger adults with diabetes.

OBJECTIVE Sertraline maintenance therapy effectively delays recurrence of major depressive disorder in adult diabetic patients when data are examined across all age-groups. A secondary analysis was performed to assess this effect in younger and older subsets of patients. RESEARCH DESIGN AND METHODS Younger (aged <55 years, n = 85) and older (aged > or =55 years, n = 67) subsets were identifie...

Gender differences in treatment response to sertraline versus imipramine in chronic depression.

OBJECTIVE The authors examined gender differences in treatment response to sertraline, a selective serotonin reuptake inhibitor (SSRI), and to imipramine, a tricyclic antidepressant, in chronic depression. METHOD A total of 235 male and 400 female outpatients with DSM-III-R chronic major depression or double depression (i.e., major depression superimposed on dysthymia) were randomly assigned ...

[Antidepressive agents to children and adolescents: continuous restriction is justified].